When Histamine Meets Hormones: Unraveling the Hidden Root Causes of Your PMS and Anxiety
- clicks4acause
- Oct 30
- 4 min read
Have you ever felt your PMS symptoms spike after indulging in chocolate, experiencing stress, or even with the changing weather?
It’s not just a hormonal issue-that’s histamine meeting your hormones at the intersection of chaos and chemistry.
The real culprit might be the interaction between histamine and hormones. This relationship can significantly impact your well-being.
In this resource article, we’ll dive into the complex relationship between histamine and hormones, explore how these factors can affect your health, and offer practical steps to support your body’s natural balance.
The Histamine-Hormone Connection
Histamine is a chemical in your body that is essential for immune function, digestion, and communication within the nervous system. But when histamine levels rise too high, they can disrupt your hormonal balance, leading to various symptoms.
Estrogen, a key hormone in women, tends to increase histamine levels. This spike can result in intense mid-cycle migraines and heightened sensitivity. Conversely, progesterone acts like a regulator, calming the effects of excess histamine.
When estrogen levels surge — for instance, during the second half of your menstrual cycle or if your body has trouble processing histamine due to genetic factors (like DAO, HNMT, MTHFR, and MAO genes) — histamine can accumulate.
This accumulation may lead to symptoms such as:
Breast tenderness, bloating, or anxiety before your period
Breast tenderness in up to 60% of women during PMS.
Bloating, which affects about 40% of women monthly.
Increased anxiety levels, reported by around 20-30% of women before their period.
Sleep disturbances correlated with heightened histamine during certain moon phases.
Significant cravings and irritability that can often feel overwhelming & “bigger than PMS”
Itchy skin or insomnia when the moon is full
This isn’t just hormones out of balance — it’s your detox + nervous system waving a white flag.
These symptoms suggest that underlying issues with your detox and nervous system might be at play, not just fluctuating hormones.
How to Support Your Terrain
Recognizing the relationship between histamine and hormones is the first step toward improving your health. Here are some actionable strategies to consider:
Nourish the Gut
The enzyme DAO, crucial for breaking down histamine, is primarily located in your gut. Supporting your gut health is key to maintaining balanced histamine levels. Consuming gut-friendly supplements like Root Restore can help promote a healthier microbiome and support mucosal healing - I LOVE the Trinity Pack for all my new clients.
Methylate Wisely
Individuals with genetic variants in MTHFR or HNMT may find it challenging to process histamine levels effectively. Taking a supplement like Clean Slate can assist in clearing histamine from your system, allowing your body to function better.
Calm the Chaos
Histamine-related anxiety can feel overwhelming — racing thoughts, restless sleep, or that wired-but-tired feeling that never fully fades.
To restore calm and focus, start by supporting your brain chemistry.
Zero-In helps balance dopamine and serotonin naturally, enhancing focus, clarity, and resilience without overstimulation.
Then, clear out hidden triggers in your environment — swap personal care and home products that contain BPA, synthetic fragrances, or estrogen-disrupting chemicals.
Your liver and hormones will thank you.
Love Your Liver (and Skin)
Your liver plays a crucial role in detoxification. Supporting liver health can help regulate histamine levels. Supplements like Give Me Back My Youth combined with krill oil can nourish collagen, improve skin elasticity by up to 30%, and promote a balance in hormones, aiding your body’s natural detox processes. Even sipping on a CLEAN mold and toxin FREE Rahm Roast cup of Coffee can support your body.
Don’t Forget the Sunshine Hormone
Vitamin D functions more like a hormone than just a vitamin. It influences estrogen, thyroid, and serotonin receptors in your body. When vitamin D levels drop in winter, it can trigger mood swings and compromise your immune system, contributing to what some call the “winter blues.” To naturally boost your vitamin D, seek out morning sunlight, exercise regularly, and consider supplements like Root Restore and Zero-In to enhance these pathways.
Rethink ReLeaf
It’s essential to recognize that your hormones are not malfunctioning. They are signals from your body. By clearing confusion and giving your body the nutrients it needs, you can restore your natural rhythm and radiance.
By addressing the root causes of your symptoms, such as histamine overload, you can nurture a healthier interaction between your histamine and hormones.
Final Thoughts
Understanding how histamine and hormones interact might seem daunting, but it is essential for reclaiming your health. By implementing the strategies discussed, you can promote your body's natural balance and lessen symptoms like PMS and anxiety.
Your body is designed to flourish. With the right dietary and lifestyle adjustments, you can bring harmony back into your life and enjoy each day to the fullest.
Adopting a well-rounded approach to health empowers you to confidently address the challenges at the intersection of histamine and hormones. Your journey to wellness starts here!
When you clear the noise and nourish the terrain, your body remembers its rhythm — and your radiance returns.
That’s Rethink ReLeaf — rooting healing from the inside out. Need Genetic Testing or Raw Data Analysis?
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